Introduction
Fear...heart palpitations...terror, a sense of impending
doom...dizziness...fear of fear. The words used to describe panic disorder
are often frightening. But there is great hope: Treatment can benefit
virtually everyone who has this condition. It is extremely important for
the person who has panic disorder to learn about the problem and the
availability of effective treatments and to seek help.
The encouraging progress in the treatment of panic disorder reflects
recent, rapid advances in scientific understanding of the brain. In fact,
the President and the U.S. Congress declared the 1990s the Decade of the
Brain. In addition to supporting intensified research on brain disorders,
the Federal Government is working to bring information about these
conditions to the people who need it.
The National Institute of Mental Health (NIMH), the Federal agency
responsible for conducting and supporting research related to mental
disorders, mental health, and the brain, is conducting a nationwide
education program on panic disorder. The program's purpose is to educate
the public and health care professionals about the disorder and encourage
people with it to obtain effective treatments.
What Is Panic Disorder?
In panic disorder, brief episodes of intense fear are accompanied by
multiple physical symptoms (such as heart palpitations and dizziness) that
occur repeatedly and unexpectedly in the absence of any external threat.
These "panic attacks," which are the hallmark of panic disorder, are
believed to occur when the brain's normal mechanism for reacting to a
threat – the so-called "fight or flight" response – becomes
inappropriately aroused. Most people with panic disorder also feel anxious
about the possibility of having another panic attack and avoid situations
in which they believe these attacks are likely to occur. Anxiety about
another attack, and the avoidance it causes, can lead to disability in
panic disorder.
Who Has Panic Disorder?
In the United States, 1.6 percent of the adult population, or more than
3 million people, will have panic disorder at some time in their lives.
The disorder typically begins in young adulthood, but older people and
children can be affected. Women are affected twice as frequently as men.
While people of all races and social classes can have panic disorder,
there appear to be cultural differences in how individual symptoms are
expressed.
Symptoms And Course Of Panic Disorder
Initial Panic Attack. Typically, a first panic attack
seems to come "out of the blue," occurring while a person is engaged in
some ordinary activity like driving a car or walking to work. Suddenly,
the person is struck by a barrage of frightening and uncomfortable
symptoms. These symptoms often include terror, a sense of unreality, or a
fear of losing control.
This barrage of symptoms usually lasts several seconds, but may
continue for several minutes. The symptoms gradually fade over the course
of about an hour. People who have experienced a panic attack can attest to
the extreme discomfort they felt and to their fear that they had been
stricken with some terrible, life-threatening disease or were "going
crazy." Often people who are having a panic attack seek help at a hospital
emergency room.
Initial panic attacks may occur when people are under considerable
stress, from an overload of work, for example, or from the loss of a
family member or close friend. The attacks may also follow surgery, a
serious accident, illness, or childbirth. Excessive consumption of
caffeine or use of cocaine or other stimulant drugs or medicines, such as
the stimulants used in treating asthma, can also trigger panic attacks.
Nevertheless panic attacks usually take a person completely by
surprise. This unpredictability is one reason they are so devastating.
Sometimes people who have never had a panic attack assume that panic is
just a matter of feeling nervous or anxious – the sort of feelings that
everyone is familiar with. In fact, even though people who have panic
attacks may not show any outward signs of discomfort, the feelings they
experience are so overwhelming and terrifying that they really believe
they are going to die, lose their minds, or be totally humiliated. These
disastrous consequences don't occur, but they seem quite likely to the
person who is suffering a panic attack.
Some people who have one panic attack, or an occasional attack, never
develop a problem serious enough to affect their lives. For others,
however, the attacks continue and cause much suffering.
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Panic Attack Symptoms
During a panic attack, some or all of the following symptoms
occur:
- Terror – a sense that something unimaginably horrible is about
to happen and one is powerless to prevent it
- Racing or pounding heartbeat
- Chest pains
- Dizziness, lightheadedness, nausea
- Difficulty breathing
- Tingling or numbness in the hands
- Flushes or chills
- Sense of unreality
- Fear of losing control, going "crazy," or doing something
embarrassing
- Fear of dying
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Panic Disorder. In panic disorder, panic
attacks recur and the person develops an intense apprehension of having
another attack. As noted earlier, this fear – called anticipatory
anxiety or fear of fear – can be present most of the time and
seriously interfere with the person's life even when a panic attack is not
in progress. In addition, the person may develop irrational fears called
phobias about situations where a panic attack has occurred. For
example, someone who has had a panic attack while driving may be afraid to
get behind the wheel again, even to drive to the grocery store.
People who develop these panic-induced phobias will tend to avoid
situations that they fear will trigger a panic attack, and their lives may
be increasingly limited as a result. Their work may suffer because they
can't travel or get to work on time. Relationships may be strained or
marred by conflict as panic attacks, or the fear of them, rule the
affected person and those close to them.
Also, sleep may be disturbed because of panic attacks that occur at
night, causing the person to awaken in a state of terror. The experience
is so harrowing that some people who have nocturnal panic attacks become
afraid to go to sleep and suffer from exhaustion. Also, even if there are
no nocturnal panic attacks, sleep may be disturbed because of chronic,
panic-related anxiety.
Many people with panic disorder remain intensely concerned about their
symptoms even after an initial visit to a physician yields no indication
of a life-threatening condition. They may visit a succession of doctors
seeking medical treatment for what they believe is heart disease or a
respiratory problem. Or their symptoms may make them think they have a
neurological disorder or some serious gastrointestinal condition. Some
patients see as many as 10 doctors and undergo a succession of expensive
and unnecessary tests in the effort to find out what is causing their
symptoms.
This search for medical help may continue a long time, because
physicians who see these patients frequently fail to diagnose panic
disorder. When doctors do recognize the condition, they sometimes explain
it in terms that suggest it is of no importance or not treatable. For
example, the doctor may say, "There's nothing to worry about, you're just
having a panic attack" or "It's just nerves." Although meant to be
reassuring, such words can be dispiriting to the worried patient whose
symptoms keep recurring. The patient needs to know that the doctor
acknowledges the disabling nature of panic disorder and that it can be
treated effectively.
Agoraphobia. Panic disorder may progress to a more
advanced stage in which the person becomes afraid of being in any place or
situation where escape might be difficult or help unavailable in the event
of a panic attack. This condition is called agoraphobia. It affects
about a third of all people with panic disorder.
Typically, people with agoraphobia fear being in crowds, standing in
line, entering shopping malls, and riding in cars or public
transportation. Often, these people restrict themselves to a "zone of
safety" that may include only the home or the immediate neighborhood. Any
movement beyond the edges of this zone creates mounting anxiety. Sometimes
a person with agoraphobia is unable to leave home alone, but can travel if
accompanied by a particular family member or friend. Even when they
restrict themselves to "safe" situations, most people with agoraphobia
continue to have panic attacks at least a few times a month.
People with agoraphobia can be seriously disabled by their condition.
Some are unable to work, and they may need to rely heavily on other family
members, who must do the shopping and run all the household errands, as
well as accompany the affected person on rare excursions outside the
"safety zone." Thus the person with agoraphobia typically leads a life of
extreme dependency as well as great discomfort.
Treatment For Panic Disorder
Treatment can bring significant relief to 70 to 90 percent of people
with panic disorder, and early treatment can help keep the disease from
progressing to the later stages where agoraphobia develops.
Before undergoing any treatment for panic disorder, a person should
undergo a thorough medical examination to rule out other possible causes
of the distressing symptoms. This is necessary because a number of other
conditions, such as excessive levels of thyroid hormone, certain types of
epilepsy, or cardiac arrhythmias, which are disturbances in the rhythm of
the heartbeat, can cause symptoms resembling those of panic disorder.
Several effective treatments have been developed for panic disorder and
agoraphobia. In 1991, a conference held at the National Institutes of
Health (NIH) under the sponsorship of the National Institute of Mental
Health and the Office of Medical Applications of Research, surveyed the
available information on panic disorder and its treatment. The conferees
concluded that a form of psychotherapy called cognitive-behavioral therapy
and medications are both effective for panic disorder. A treatment should
be selected according to the individual needs and preferences of the
patient, the panel said, and any treatment that fails to produce an effect
within 6 to 8 weeks should be reassessed.
Cognitive-Behavioral Therapy. This is a combination of
cognitive therapy, which can modify or eliminate thought patterns
contributing to the patient's symptoms, and behavioral therapy,
which aims to help the patient change his or her behavior.
Typically the patient undergoing cognitive-behavioral therapy meets
with a therapist for 1 to 3 hours a week. In the cognitive portion of the
therapy, the therapist usually conducts a careful search for the thoughts
and feelings that accompany the panic attacks. These mental events are
discussed in terms of the "cognitive model" of panic attacks.
The cognitive model states that individuals with panic disorder often
have distortions in their thinking, of which they may be unaware, and
these may give rise to a cycle of fear. The cycle is believed to operate
this way: First the individual feels a potentially worrisome sensation
such as an increasing heart rate, tightened chest muscles, or a queasy
stomach. This sensation may be triggered by some worry, an unpleasant
mental image, a minor illness, or even exercise. The person with panic
disorder responds to the sensation by becoming anxious. The initial
anxiety triggers still more unpleasant sensations, which in turn heighten
anxiety, giving rise to catastrophic thoughts. The person thinks "I am
having a heart attack" or "I am going insane," or some similar thought. As
the vicious cycle continues, a panic attack results. The whole cycle might
take only a few seconds, and the individual may not be aware of the
initial sensations or thoughts.
Proponents of this theory point out that, with the help of a skilled
therapist, people with panic disorder often can learn to recognize the
earliest thoughts and feelings in this sequence and modify their responses
to them. Patients are taught that typical thoughts such as "That terrible
feeling is getting worse!" or "I'm going to have a panic attack" or "I'm
going to have a heart attack" can be replaced with substitutes such as
"It's only uneasiness – it will pass" that help to reduce anxiety and ward
off a panic attack. Specific procedures for accomplishing this are taught.
By modifying thought patterns in this way, the patient gains more control
over the problem.
Often the therapist will provide the patient with simple guidelines to
follow when he or she can feel that a panic attack is approaching. One
therapist has offered a set of strategies that have helped some of her
patients to cope with panic attacks.
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Strategies for Coping with Panic
- Remember that although your feelings and symptoms are very
frightening, they are not dangerous or harmful.
- Understand that what you are experiencing is just an
exaggeration of your normal bodily reactions to stress.
- Do not fight your feelings or try to wish them away. The more
you are willing to face them, the less intense they will become.
- Do not add to your panic by thinking about what "might"
happen. If you find yourself asking "What if?" tell yourself "So
what!"
- Stay in the present. Notice what is really happening to you as
opposed to what you think might happen.
- Label your fear level from zero to ten and watch it go up and
down. Notice that it does not stay at a very high level for more
than a few seconds.
- When you find yourself thinking about the fear, change your
"what if" thinking. Focus on and carry out a simple and manageable
task such as counting backward from from 100 by 3's or snapping a
rubber band on your wrist.
- Notice that when you stop adding frightening thoughts to your
fear, it begins to fade.
- When the fear comes, expect and accept it. Wait and give it
time to pass without running away from it.
- Be proud of yourself for your progress thus far, and think
about how good you will feel when you succeed this time.
(Courtesy Jerilyn Ross, M.A.,
L.I.C.S.W., The Ross Center for Anxiety and Related Disorders, Inc.,
Washington, DC. Adapted from Mathews et al., 1981.)
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In cognitive therapy, discussions between the patient and
the therapist are not usually focused on the patient's past, as is the
case with some forms of psychotherapy. Instead, conversations focus on the
difficulties and successes the patient is having at the present time, and
on skills the patient needs to learn.
The behavioral portion of cognitive-behavioral therapy may involve
systematic training in relaxation techniques. By learning to relax, the
patient may acquire the ability to reduce generalized anxiety and stress
that often sets the stage for panic attacks.
Breathing exercises are often included in the behavioral
therapy. The patient learns to control his or her breathing and avoid
hyperventilation – a pattern of rapid, shallow breathing that can trigger
or exacerbate some people's panic attacks.
Another important aspect of behavioral therapy is exposure to internal
sensations called interoceptive exposure. During interoceptive
exposure the therapist will do an individual assessment of internal
sensations associated with panic. Depending on the assessment, the
therapist may then encourage the patient to bring on some of the
sensations of a panic attack by, for example, exercising to increase heart
rate, breathing rapidly to trigger lightheadedness and respiratory
symptoms, or spinning around to trigger dizziness. Exercises to produce
feelings of unreality may also be used. Then the therapist teaches the
patient to cope effectively with these sensations and to replace alarmist
thoughts such as "I am going to die," with more appropriate ones, such as
"It's just a little dizziness – I can handle it."
Another important aspect of behavioral therapy is "in vivo" or
real-life exposure. The therapist and the patient determine whether
the patient has been avoiding particular places and situations, and which
patterns of avoidance are causing the patient problems. They agree to work
on the avoidance behaviors that are most seriously interfering with the
patient's life. For example, fear of driving may be of paramount
importance for one patient, while inability to go to the grocery store may
be, at most, handicapping for another.
Some therapists will go to an agoraphobic patient's home to conduct the
initial sessions. Often therapists take their patients on excursions to
shopping malls and other places the patients have been avoiding. Or they
may accompany their patients who are trying to overcome fear of driving a
car.
The patient approaches a feared situation gradually, attempting to stay
in spite of rising levels of anxiety. In this way the patient sees that as
frightening as the feelings are, they are not dangerous, and they do pass.
On each attempt, the patient faces as much fear as he or she can stand.
Patients find that with this step-by-step approach, aided by encouragement
and skilled advice from the therapist, they can gradually master their
fears and enter situations that had seemed unapproachable.
Many therapists assign the patient "homework" to do between sessions.
Sometimes patients spend only a few sessions in one-on-one contact with a
therapist and continue to work on their own with the aid of a printed
manual.
Often the patient will join a therapy group with others striving to
overcome panic disorder or phobias, meeting with them weekly to discuss
progress, exchange encouragement, and receive guidance from the therapist.
Cognitive-behavioral therapy generally requires at least 8 to 12 weeks.
Some people may need a longer time in treatment to learn and implement the
skills. This kind of therapy, which is reported to have a low relapse
rate, is effective in eliminating panic attacks or reducing their
frequency. It also reduces anticipatory anxiety and the avoidance of
feared situations.
Treatment with Medications. In this treatment approach,
which is also called pharmacotherapy, a prescription medication is
used both to prevent panic attacks or reduce their frequency and severity,
and to decrease the associated anticipatory anxiety. When patients find
that their panic attacks are less frequent and severe, they are
increasingly able to venture into situations that had been off-limits to
them. In this way, they benefit from exposure to previously feared
situations as well as from the medication.
The three groups of medications most commonly used are the tricyclic
antidepressants, the high-potency benzodiazepines, and the
monoamine oxidase inhibitors (MAOIs). Determination of which drug
to use is based on considerations of safety, efficacy, and the personal
needs and preferences of the patient. Some information about each of the
classes of drugs follows.
The tricyclic antidepressants were the first medications shown to have
a beneficial effect against panic disorder. Imipramine is the tricyclic
most commonly used for this condition. When imipramine is prescribed, the
patient usually starts with small daily doses that are increased every few
days until an effective dosage is reached. The slow introduction of
imipramine helps minimize side effects such as dry mouth, constipation,
and blurred vision. People with panic disorder, who are inclined to be
hypervigilant about physical sensations, often find these side effects
disturbing at the outset. Side effects usually fade after the patient has
been on the medication a few weeks.
It usually takes several weeks for imipramine to have a beneficial
effect on panic disorder. Most patients treated with imipramine will be
panic-free within a few weeks or months. Treatment generally lasts from 6
to 12 months. Treatment for a shorter period of time is possible, but
there is substantial risk that when imipramine is stopped, panic attacks
will recur. Extending the period of treatment to 6 months to a year may
reduce this risk of a relapse. When the treatment period is complete, the
dosage of imipramine is tapered over a period of several weeks.
The high-potency benzodiazepines are a class of medications that
effectively reduce anxiety. Alprazolam, clonazepam, and lorazepam are
medications that belong to this class. They take effect rapidly, have few
bothersome side effects, and are well tolerated by the majority of
patients. However, some patients, especially those who have had problems
with alcohol or drug dependency, may become dependent on benzodiazepines.
Generally, the physician prescribing one of these drugs starts the
patient on a low dose and gradually increases it until panic attacks
cease. This procedure minimizes side effects.
Treatment with high-potency benzodiazepines is usually continued for 6
months to a year. One drawback of these medications is that patients may
experience withdrawal symptoms – malaise, weakness, and other unpleasant
effects – when the treatment is discontinued. Reducing the dose gradually
generally minimizes these problems. There may also be a recurrence of
panic attacks after the medication is withdrawn.
Of the MAOIs, a class of antidepressants which have been shown to be
effective against panic disorder, phenelzine is the most commonly used.
Treatment with phenelzine usually starts with a relatively low daily
dosage that is increased gradually until panic attacks cease or the
patient reaches a maximum dosage of about 100 milligrams a day.
Use of phenelzine or any other MAOI requires the patient to observe
exacting dietary restrictions, because there are foods and prescription
drugs and certain substances of abuse that can interact with the MAOI to
cause a sudden, dangerous rise in blood pressure. All patients who are
taking MAOIs should obtain their physician's guidance concerning dietary
restrictions and should consult with their physician before using any
over-the-counter or prescription medications.
As in the case of the high-potency benzodiazepines and imipramine,
treatment with phenelzine or another MAOI generally lasts 6 months to a
year. At the conclusion of the treatment period, the medication is
gradually tapered.
Newly available antidepressants such as fluoxetine (one of a class of
new agents called serotonin reuptake inhibitors) appear to be effective in
selected cases of panic disorder. As with other anti-panic medications, it
is important to start with very small doses and gradually increase the
dosage.
Scientists supported by NIMH are seeking ways to improve drug treatment
for panic disorder. Studies are underway to determine the optimal duration
of treatment with medications, who they are most likely to help, and how
to moderate problems associated with withdrawal.
Combination Treatments. Many believe that a combination
of medication and cognitive-behavioral therapy represents the best
alternative for the treatment of panic disorder. The combined approach is
said to offer rapid relief, high effectiveness, and a low relapse rate.
However, there is a need for more research studies to determine whether
this is in fact the case.
Comparing medications and psychological treatments, and determining how
well they work in combination, is the goal of several NIMH-supported
studies. The largest of these is a 4-year clinical trial that will include
480 patients and involve four centers at the State University of New York
at Albany, Cornell University, Hillside Hospital/Columbia University, and
Yale University. This study is designed to determine how treatment with
imipramine compares with a cognitive-behavioral approach, and whether
combining the two yields benefits over either method alone.
Psychodynamic Treatment. This is a form of "talk therapy"
in which the therapist and the patient, working together, seek to uncover
emotional conflicts that may underlie the patient's problems. By talking
about these conflicts and gaining a better understanding of them, the
patient is helped to overcome the problems. Often, psychodynamic treatment
focuses on events of the past and making the patient aware of the
ramifications of long-buried problems.
Although psychodynamic approaches may help to relieve the stress that
contributes to panic attacks, they do not seem to stop the attacks
directly. In fact, there is no scientific evidence that this form of
therapy by itself is effective in helping people to overcome panic
disorder or agoraphobia. However, if a patient's panic disorder occurs
along with some broader and pre-existing emotional disturbance,
psychodynamic treatment may be a helpful addition to the overall treatment
program.
When Panic Recurs
Panic disorder is often a chronic, relapsing illness. For many people,
it gets better at some times and worse at others. If a person gets
treatment and appears to have largely overcome the problem, it can still
worsen later for no apparent reason. These recurrences should not cause a
person to despair or consider himself or herself a "treatment failure."
Recurrences can be treated effectively, just like an initial episode.
In fact, the skills that a person learns in dealing with the initial
episode can be helpful in coping with any setbacks. Many people who have
overcome panic disorder once or a few times find that, although they still
have an occasional panic attack, they are now much better able to deal
with the problem. Even though it is not fully cured, it no longer
dominates their lives, or the lives of those around them.
Coexisting Conditions
At the NIH conference on panic disorder, the panel recommended that
patients be carefully evaluated for other conditions that may be present
along with panic disorder. These may influence the choice of treatment,
the panel noted. The following are among the conditions frequently found
to coexist with panic disorder:
Simple Phobias. People with panic disorder often develop
irrational fears of specific events or situations that they associate with
the possibility of having a panic attack. Fear of heights and fear of
crossing bridges are examples of simple phobias. Generally, these fears
can be resolved through repeated exposure to the dreaded situations, while
practicing specific cognitive-behavioral techniques to become less
sensitive to them.
Social Phobia. This is a persistent dread of situations
in which the person is exposed to possible scrutiny by others and fears
acting in a way that will be embarrassing or humiliating. Social phobia
can be treated effectively with cognitive-behavioral therapy or
medications, or both.
Depression. About half of panic disorder patients will
have an episode of clinical depression sometime during their lives. Major
depression is marked by persistent sadness or feelings of emptiness, a
sense of hopelessness, and other symptoms.
When major depression occurs, it can be treated effectively with one of
several antidepressant drugs, or, depending on its severity, by
cognitive-behavioral therapies.
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Symptoms of Depression
- Persistent sadness or feelings of emptiness
- A sense of hopelessness
- Feelings of guilt
- Problems sleeping
- Loss of interest or pleasure in ordinary activities
- Fatigue or decreased energy
- Difficulty concentrating, remembering, and making decisions
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Obsessive-Compulsive Disorder (OCD). In OCD, a
person becomes trapped in a pattern of repetitive thoughts and behaviors
that are senseless and distressing but extremely difficult to overcome.
Such rituals as counting, prolonged handwashing, and repeatedly checking
for danger may occupy much of the person's time and interfere with other
activities. Today, OCD can be treated effectively with medications or
cognitive-behavioral therapies.
Alcohol Abuse. About 30 percent of people with panic
disorder abuse alcohol. A person who has alcoholism in addition to panic
disorder needs specialized care for the alcoholism along with treatment
for the panic disorder. Often the alcoholism will be treated first.
Drug Abuse. As in the case of alcoholism, drug abuse is
more common in people with panic disorder than in the population at large.
In fact, about 17 percent of people with panic disorder abuse drugs. The
drug problems often need to be addressed prior to treatment for panic
disorder.
Suicidal Tendencies. Recent studies in the general
population have suggested that suicide attempts are more common among
people who have panic attacks than among those who do not have a mental
disorder. Also, it appears that people who have both panic disorder and
depression are at elevated risk for suicide. (However, anxiety disorder
experts who have treated many patients emphasize that it is extremely
unlikely that anyone would attempt to harm himself or herself during a
panic attack.)
Anyone who is considering suicide needs immediate attention from a
mental health professional or from a school counselor, physician, or
member of the clergy. With appropriate help and treatment, it is possible
to overcome suicidal tendencies.
There are also certain physical conditions that are often associated
with panic disorder:
Irritable Bowel Syndrome. The person with this syndrome
experiences intermittent bouts of gastrointestinal cramps and diarrhea or
constipation, often occurring during a period of stress. Because the
symptoms are so pronounced, panic disorder is often not diagnosed when it
occurs in a person with irritable bowel syndrome.
Mitral Valve Prolapse. This condition involves a defect
in the mitral valve, which separates the two chambers on the left side of
the heart. Each time the heart muscle contracts in people with this
condition, tissue in the mitral valve is pushed for an instant into the
wrong chamber. The person with the disorder may experience chest pain,
rapid heartbeat, breathing difficulties, and headache. People with mitral
valve prolapse may be at higher than usual risk of having panic disorder,
but many experts are not convinced this apparent association is real.
Causes Of Panic Disorder
The National Institute of Mental Health supports a sizable and
multifaceted research program on panic disorder – its causes, diagnosis,
treatment, and prevention. This research involves studies of panic
disorder in human subjects and investigations of the biological basis for
anxiety and related phenomena in animals. It is part of a massive effort
to overcome the major mental disorders, an effort that started during the
1990s – the Decade of the Brain. Here is a description of some of the most
important new research on panic disorder and its causes.
Genetics. Panic disorder runs in families. One study has
shown that if one twin in a genetically identical pair has panic disorder,
it is likely that the other twin will also. Fraternal, or non-identical
twin pairs do not show this high degree of "concordance" with respect to
panic disorder. Thus, it appears that some genetic factor, in combination
with environment, may be responsible for vulnerability to this condition.
NIMH-supported scientists are studying families in which several
individuals have panic disorder. The aim of these studies is to identify
the specific gene or genes involved in the condition. Identification of
these genes may lead to new approaches for diagnosing and treating panic
disorder.
Brain and Biochemical Abnormalities. One line of evidence
suggests that panic disorder may be associated with increased activity in
the hippocampus and locus coeruleus, portions of the brain that monitor
external and internal stimuli and control the brain's responses to them.
Also, it has been shown that panic disorder patients have increased
activity in a portion of the nervous system called the adrenergic system,
which regulates such physiological functions as heart rate and body
temperature. However, it is not clear whether these increases reflect the
anxiety symptoms or whether they cause them.
Another group of studies suggests that people with panic disorder may
have abnormalities in their benzodiazepine receptors, brain components
that react with anxiety-reducing substances within the brain.
In conducting their research, scientists can use several different
techniques to provoke panic attacks in people who have panic disorder. The
best known method is intravenous administration of sodium lactate, the
same chemical that normally builds up in the muscles during heavy
exercise. Other substances that can trigger panic attacks in susceptible
people include caffeine (generally 5 or more cups of coffee are required).
Hyperventilation and breathing air with a higher-than-usual level of
carbon dioxide can also trigger panic attacks in people with panic
disorder.
Because these provocations generally do not trigger panic
attacks in people who do not have panic disorder, scientists have
inferred that individuals who have panic disorder are biologically
different in some way from people who do not. However, it is also true
that when the people prone to panic attacks are told in advance about the
sensations these provocations will cause, they are much less likely to
panic. This suggests that there is a strong psychological component, as
well as a biological one, to panic disorder.
NIMH-supported investigators are examining specific parts of the brain
and central nervous system to learn which ones play a role in panic
disorder, and how they may interact to give rise to this condition. Other
studies funded by the Institute are under way to determine what happens
during "provoked" panic attacks, and to investigate the role of breathing
irregularities in anxiety and panic attacks.
Animal Studies. Studies of anxiety in animals are
providing NIMH-sponsored researchers with clues to the underlying causes
of this phenomenon. One series of studies involves an inbred line of
pointer dogs that exhibit extreme, abnormal fearfulness when approached by
humans or startled by loud noises. In contrast with normal pointers, these
nervous dogs have been found to react more strongly to caffeine and to
have brain tissue that is richer in receptors for adenosine, a naturally
occurring sedative that normally exerts a calming effect within the brain.
Further study of these animals is expected to reveal how a genetic
predisposition toward anxiety is expressed in the brain.
Other animal studies involve macaque monkeys. Some of these animals
exhibit anxiety when challenged with an infusion of lactate, much like
people with panic disorder. Other macaques do not exhibit this response.
NIMH-supported scientists are attempting to determine how the brains of
the responsive and non-responsive monkeys differ. This research should
provide additional information on the causes of panic disorder.
In addition, research with rats is exploring the effect of various
medications on the parts of the brain involved in anxiety. The aim is to
develop a clearer picture of which components of the brain are responsible
for anxiety, and to learn how their actions can be brought under better
control.
Cognitive Factors. Scientists funded by NIMH are
investigating the basic thought processes and emotions that come into play
during a panic attack and those that contribute to the development and
persistence of agoraphobia. The Institute also supports research
evaluating the impact of various versions of cognitive-behavioral therapy
to determine which variants of the procedure are effective for which
people. The NIMH panic disorder research program will also explore the
effects of interpersonal stress such as marital conflict on panic disorder
with agoraphobia and determine if including spouses in the
cognitive-behavioral treatment of the condition improves outcome.
Finding Help For Panic Disorder
Often the person with panic disorder must undertake a strenuous search
to find a therapist who is familiar with the most effective treatments for
the condition. A list of places to start follows. The Anxiety Disorders
Association of America can provide a list of professionals in your area
who specialize in the treatment of panic disorder and other anxiety
disorders.
Self-help and support groups are the least expensive
approach to managing panic disorder, and are helpful for some people. A
group of about 5 to 10 people meet weekly and share their experiences,
encouraging each other to venture into feared situations and cope
effectively with panic attacks. Group members are in charge of the
sessions. Often family members are invited to attend these groups, and at
times a therapist or other panic disorder expert may be brought in to
share insights with group members. Information on self-help groups in
specific areas of the country can be obtained from the Anxiety Disorders
Association of America.
Sources of Referral to Professional Help for Panic Disorder.
Here are the types of people and places that will make a referral to,
or provide, diagnostic and treatment services for a person with symptoms
resembling those described in this brochure. Also check the Yellow Pages
under "mental health," "health," "anxiety," "suicide prevention,"
"hospitals," "physicians," "psychiatrists," "psychologists," or "social
workers" for phone numbers and addresses.
- Family doctors
- Clergy
- Mental health specialists, such as psychiatrists, psychologists,
social workers, or mental health counselors
- Health maintenance organizations
- Community mental health centers
- Hospital psychiatry departments and outpatient clinics
- University- or medical school-affiliated treatment or research
programs
- State hospital outpatient clinics
- Family service/social agencies
- Private clinics and facilities
- Employee assistance programs
- Local medical, psychiatric, or psychological societies
There is a detailed list of organizations and contact information
below.
Help For The Family
When one member of a family has panic disorder, the entire family is
affected by the condition. Family members may be frustrated in their
attempts to help the affected member cope with the disorder, overburdened
by taking on additional responsibilities, and socially isolated. Family
members must encourage the person with panic disorder to seek the help of
a qualified mental health professional. Also, it is often helpful for
family members to attend an occasional treatment or self-help session or
seek the guidance of the therapist in dealing with their feelings about
the disorder.
Certain strategies, such as encouraging the person with panic disorder
to go at least partway toward a place or situation that is feared, can be
helpful. The director of one anxiety disorder clinic has developed a list
of suggestions for family members who want to help loved ones cope with an
anxiety disorder. By their skilled and caring efforts to help, family
members can aid the person with panic disorder in making a recovery.
Also, it may be valuable for family members to join or form a support
group to share information and offer mutual encouragement.
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What to Do if a Family Member Has an Anxiety
Disorder
- Don't make assumptions about what the affected person needs;
ask them.
- Be predictable; don't surprise them.
- Let the person with the disorder set the pace for recovery.
- Find something positive in every experience. If the affected
person is only able to go partway to a particular goal, such as a
movie theater or party, consider that an achievement rather than a
failure.
- Don't enable avoidance: negotiate with the person with panic
disorder to take one step forward when he or she wants to avoid
something.
- Don't sacrifice your own life and build resentments.
- Don't panic when the person with the disorder panics.
- Remember that it's alright to be anxious yourself; it's
natural for you to be concerned and even worried about the person
with panic disorder.
- Be patient and accepting, but don't settle for the affected
person being permanently disabled.
- Say: "You can do it no matter how you feel. I am proud of you.
Tell me what you need now. Breathe slow and low. Stay in the
present. It's not the place that's bothering you, it's the
thought. I know that what you are feeling is painful, but it's not
dangerous. You are courageous."
Don't say: "Relax. Calm down. Don't be anxious.
Let's see if you can do this (i.e., setting up a test for the
affected person). You can fight this. What should we do next?
Don't be ridiculous. You have to stay. Don't be a
coward."
(Adapted from Sally Winston, Psy.D.,
The Anxiety and Stress Disorders Institute of Maryland, Towson,
MD, 1992.)
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Keeping on Top of Your Condition
Keeping in tune with your disease or condition not only makes treatment less intimidating but also increases its chance of success, and has been shown to lower a patients risk of complications. As well, as an informed patient, you are better able to discuss your condition and treatment options with your physician.
A new service available to patients provides a convenient means of staying informed, and ensures that the information is both reliable and accurate. If you wish to find out more about HealthNewsflash's innovative service, take the tour.
For More Information On Panic Disorder And Related
Conditions
American Psychiatric Association 1400 K Street, N.W.
Washington, DC 20005 http://www.psych.org
American Psychological Association 750 First Street, N.E.
Washington, DC 20002 http://www.apa.org
Anxiety Disorders Association of America 11900 Parklawn Drive,
Suite 100 Rockville, MD 20852 (Include $3 for postage and
handling.) http://www.adaa.org
Association for the Advancement of Behavior Therapy 305 Seventh
Avenue New York, NY 10001 http://www.aabt.org
National Alliance for the Mentally Ill 200 North Glebe Road, Suite
1015 Arlington, VA 22203-3754 http://www.nami.org
National Anxiety Foundation 3135 Custer Drive Lexington, KY
40517-4001
National Depressive and Manic Depressive Association 740 North
Franklin Street, Suite 301 Chicago, IL 60601
http://www.ndmda.org
National Institute of Mental Health 6001 Executive Boulevard, Rm.
8184, MSC 9663 Bethesda, MD 20892-9663 http://www.nimh.nih.gov
National Mental Health Association 1201 Prince Street
Alexandria, VA 22314-2971 http://www.nmha.org
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